Serum bilirubin and chronic obstructive pulmonary disease (COPD): a systematic review.

ABSTRACT:

Background

Bilirubin is a potent antioxidant and higher serum bilirubin levels have been associated with improved COPD outcomes. We performed a systematic review to evaluate the association between serum bilirubin levels and lung function (FEV₁), prevalence/incidence of COPD, acute exacerbations of COPD, respiratory health status, and mortality.

Methods

MEDLINE® and Embase were searched using Ovid® (search updated October 1st, 2019). We included studies that measured serum bilirubin levels and outcomes of interest in adults with or without underlying lung disease. We excluded studies of those with liver disease or drug-induced elevations in bilirubin. We used the Newcastle-Ottawa scale to assess individual study risk of bias (ROB) and the US Agency for Healthcare

SUBMITTER: MacDonald DM 

PROVIDER: S-EPMC7816373 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature