The gut microbiome: a key player in the complexity of amyotrophic lateral sclerosis (ALS).

ABSTRACT:

Background

Much progress has been made in mapping genetic abnormalities linked to amyotrophic lateral sclerosis (ALS), but the majority of cases still present with no known underlying cause. Furthermore, even in families with a shared genetic abnormality there is significant phenotypic variability, suggesting that non-genetic elements may modify pathogenesis. Identification of such disease-modifiers is important as they might represent new therapeutic targets. A growing body of research has begun to shed light on the role played by the gut microbiome in health and disease with a number of studies linking abnormalities to ALS.

Main body

The microbiome refers to the genes belonging to the myriad different microorganisms that live within and upon us, collectively known as the m

SUBMITTER: Boddy SL 

PROVIDER: S-EPMC7816375 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature