Insight into the practical performance of RT-PCR testing for SARS-CoV-2 using serological data: a cohort study.

ABSTRACT:

Background

Virological detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through RT-PCR has limitations for surveillance. Serological tests can be an important complementary approach. We aimed to assess the practical performance of RT-PCR-based surveillance protocols and determine the extent of undetected SARS-CoV-2 infection in Shenzhen, China.

Methods

We did a cohort study in Shenzhen, China and attempted to recruit by telephone all RT-PCR-negative close contacts (defined as those who lived in the same residence as, or shared a meal, travelled, or socially interacted with, an index case within 2 days before symptom onset) of all RT-PCR-confirmed cases of SARS-CoV-2 detected since January, 2020, via contact tracing. We measured anti-SARS-CoV-2 antibo

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC7816573 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature