Clade GR and clade GH isolates of SARS-CoV-2 in Asia show highest amount of SNPs.

ABSTRACT: Clades are monophyletic groups composed of a common ancestor and all its lineal descendants. As the propensity of virulence of a disease depends upon the type of clade the virus belongs to and it causes different fatality rates of disease in different countries, so the clade-wise analysis of SARS-CoV-2 isolates collected from different countries can illuminate the actual evolutionary relationships between them. In this study, 1566 SARS-CoV-2 genome sequences across ten Asian countries are collected, clustered, and characterized based on the clade they belong to. The isolates are compared to the Wuhan reference sequence" hCoV-19/Wuhan/WIV04/19″ to identify the mutations that occurred at different protein regions. Structural changes in amino acids due to mutations lead to functional instabil

SUBMITTER: Sengupta A 

PROVIDER: S-EPMC7816605 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature