Better prognosis in females with severe COVID-19 pneumonia: possible role of inflammation as potential mediator.

ABSTRACT:

Objectives

Sex differences in COVID-19 severity and mortality have been described. Key aims of this analysis were to compare the risk of invasive mechanical ventilation (IMV) and mortality by sex and to explore whether variation in specific biomarkers could mediate this difference.

Methods

This was a retrospective, observational cohort study among patients with severe COVID-19 pneumonia. A survival analysis was conducted to compare time to the composite endpoint of IMV or death according to sex. Interaction was formally tested to compare the risk difference by sex in sub-populations. Mediation analysis with a binary endpoint IMV or death (yes/no) by day 28 of follow-up for a number of inflammation/coagulation biomarkers in the context of counterfactual prediction was also co

SUBMITTER: Mussini C 

PROVIDER: S-EPMC7816626 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature