Quantitative differences between intra-host HCV populations from persons with recently established and persistent infections.

ABSTRACT: Detection of incident hepatitis C virus (HCV) infections is crucial for identification of outbreaks and development of public health interventions. However, there is no single diagnostic assay for distinguishing recent and persistent HCV infections. HCV exists in each infected host as a heterogeneous population of genomic variants, whose evolutionary dynamics remain incompletely understood. Genetic analysis of such viral populations can be applied to the detection of incident HCV infections and used to understand intra-host viral evolution. We studied intra-host HCV populations sampled using next-generation sequencing from 98 recently and 256 persistently infected individuals. Genetic structure of the populations was evaluated using 245,878 viral sequences from these individuals and a set

SUBMITTER: Icer Baykal PB 

PROVIDER: S-EPMC7816669 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature