Spatial Engineering Direct Cooperativity between Binding Sites for Uranium Sequestration.

ABSTRACT: Preorganization is a basic design principle used by nature that allows for synergistic pathways to be expressed. Herein, a full account of the conceptual and experimental development from randomly distributed functionalities to a convergent arrangement that facilitates cooperative binding is given, thus conferring exceptional affinity toward the analyte of interest. The resulting material with chelating groups populated adjacently in a spatially locked manner displays up to two orders of magnitude improvement compared to a random and isolated manner using uranium sequestration as a model application. This adsorbent shows exceptional extraction efficiencies, capable of reducing the uranium concentration from 5 ppm to less than 1 ppb within 10 min, even though the system is permeated with hi

SUBMITTER: Sun Q 

PROVIDER: S-EPMC7816700 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature