Microtubule Engagement with Taxane Is Altered in Taxane-Resistant Gastric Cancer.

ABSTRACT:

Purpose

Although taxane-based therapy is standard treatment for advanced gastric cancer, a majority of patients exhibit intrinsic resistance to taxanes. Here, we aim to identify the molecular basis of taxane resistance in gastric cancer.

Experimental design

We performed a post hoc analysis of the TAX-325 clinical trial and molecular interrogation of gastric cancer cell lines to assess the benefit of docetaxel in diffuse (DIF-GC) versus intestinal (INT-GC) gastric cancer. We assessed drug-induced microtubule stabilization in gastric cancer cells and in biopsies of patients with gastric cancer treated with taxanes. We performed transcriptome analysis in taxane-treated gastric cancer cells and patients to identify molecular drivers of taxane resistance.

Results

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SUBMITTER: Galletti G 

PROVIDER: S-EPMC7816968 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature