Plasma proteins associated with cardiovascular death in patients with chronic coronary heart disease: A retrospective study.

ABSTRACT:

Background

Circulating biomarkers are associated with the development of coronary heart disease (CHD) and its complications by reflecting pathophysiological pathways and/or organ dysfunction. We explored the associations between 157 cardiovascular (CV) and inflammatory biomarkers and CV death using proximity extension assays (PEA) in patients with chronic CHD.

Methods and findings

The derivation cohort consisted of 605 cases with CV death and 2,788 randomly selected non-cases during 3-5 years follow-up included in the STabilization of Atherosclerotic plaque By Initiation of darapLadIb TherapY (STABILITY) trial between 2008 and 2010. The replication cohort consisted of 245 cases and 1,042 non-cases during 12 years follow-up included in the Ludwigshafen Risk and Cardiovascular

SUBMITTER: Wallentin L 

PROVIDER: S-EPMC7817029 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature