Association of aerobic glycolysis with the structural connectome reveals a benefit-risk balancing mechanism in the human brain.

ABSTRACT: Aerobic glycolysis (AG), that is, the nonoxidative metabolism of glucose, contributes significantly to anabolic pathways, rapid energy generation, task-induced activity, and neuroprotection; yet high AG is also associated with pathological hallmarks such as amyloid-β deposition. An important yet unresolved question is whether and how the metabolic benefits and risks of brain AG is structurally shaped by connectome wiring. Using positron emission tomography and magnetic resonance imaging techniques as well as computational models, we investigate the relationship between brain AG and the macroscopic connectome. Specifically, we propose a weighted regional distance-dependent model to estimate the total axonal projection length of a brain node. This model has been validated in a macaque connec

SUBMITTER: Chen Y 

PROVIDER: S-EPMC7817189 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature