Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa.

ABSTRACT:

Background

Phylogeny construction can help to reveal evolutionary relatedness among molecular sequences. The spike (S) gene of SARS-CoV-2 is the subject of an immune selective pressure which increases the variability in such region. This study aimed to identify mutations in the S gene among SARS-CoV-2 sequences collected in the Middle East and North Africa (MENA), focusing on the D614G mutation, that has a presumed fitness advantage. Another aim was to analyze the S gene sequences phylogenetically.

Methods

The SARS-CoV-2 S gene sequences collected in the MENA were retrieved from the GISAID public database, together with its metadata. Mutation analysis was conducted in Molecular Evolutionary Genetics Analysis software. Phylogenetic analysis was don

SUBMITTER: Sallam M 

PROVIDER: S-EPMC7817394 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature