Sex disparities in waitlisting and liver transplant for acute liver failure.

ABSTRACT:

Background & aims

Sex disparities in liver transplantation (LT) for chronic liver disease have been described. It is unclear if similar disparities exist for acute liver failure (ALF).

Methods

Adults waitlisted for LT from 2002 to 2016 with ALF were investigated using the United Network of Organ Sharing database. Clinical characteristics and causative aetiologies were compared between men and women who were waitlisted Status-1. Differences in LT, waitlist removal, and 1-year post-transplant survival were explored.

Results

Of 8,408 patients waitlisted for LT with ALF, 41.3% of men and 63.9% of women were waitlisted Status-1 (p <0.001). Women had significantly higher international normalised ratio, higher frequency of grade 3-4 hepatic encephalopathy, and differe

SUBMITTER: Nephew LD 

PROVIDER: S-EPMC7817503 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature