BRAF ^AMP Frequently Co-occurs With IDH1/2, TP53, and ATRX Mutations in Adult Patients With Gliomas and Is Associated With Poorer Survival Than That of Patients Harboring BRAF ^V600E.

ABSTRACT: Abnormal RAS/RAF signaling plays a critical role in glioma. Although it is known that the V600E mutation of v-raf murine viral oncogene homolog B1 (BRAF ^V600E) and BRAF amplification (BRAF ^AMP) both result in constitutive activation of the RAS/RAF pathway, whether BRAF ^V600E and BRAF ^AMP have different effects on the survival of glioma patients needs to be clarified. Using cBioPortal, we retrieved studies of both mutations and copy number variations of the BRAF gene in CNS/brain tumors and investigated data from 69 nonredundant glioma patients. The BRAF mutation group had significantly more male patients (64.00% vs. 36.84%; P = 0.046) and a higher occurrence of glioblastoma multiforme (66.00

SUBMITTER: Da R 

PROVIDER: S-EPMC7817544 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature