Prognostic significance and therapeutic potential of the immune checkpoint VISTA in pancreatic cancer.

ABSTRACT:

Objective

V-domain Ig suppressor of T cell activation (VISTA) is a novel immune checkpoint protein that belongs to the B7 family. The aim of this study was to investigate the prognostic significance and therapeutic potential of VISTA in patients with pancreatic cancer.

Methods

Using immunohistochemistry (IHC), we examined the expression of VISTA and demonstrated the associations between the VISTA and overall survival in 223 PDAC patients from 2 different unrelated retrospective cohorts. The multiplex immunofluorescence was performed to illuminate the relationship between VISTA expression and tumor-infiltrating immune cell subclusters of PDAC. We also verified the findings in The Cancer Genome Atlas (TCGA) dataset. The anti-tumor effect of anti-VISTA therapy was studied by th

SUBMITTER: Hou Z 

PROVIDER: S-EPMC7817580 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature