Functional Characterization of Ly49⁺CD8 T-Cells in Both Normal Condition and During Anti-Viral Response.

ABSTRACT: The role of Ly49⁺CD8 T-cells in the immune system is not clear. Previously, several papers suggested Ly49⁺CD8 T-cells as immunosuppressors, while multiple studies also suggested their role as potent participants of the immune response. The mechanism of Ly49 expression on CD8 T-cells is also not clear. We investigated phenotype, functions, and regulation of Ly49 expression on murine CD8 T-cells in both normal state and during LCMV infection. CD8 T-cells express different Ly49 receptors compared with NK-cells. In intact mice, Ly49⁺CD8 T-cells have a phenotype similar to resting central memory CD8 T-cells and do not show impaired proliferation and cytokine production. Conventional CD8 T-cells upregulate Ly49 receptors during TCR-induced stimulation, and IL-2,

SUBMITTER: Shytikov D 

PROVIDER: S-EPMC7817614 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature