UPR^mt scales mitochondrial network expansion with protein synthesis via mitochondrial import in Caenorhabditis elegans.

ABSTRACT: As organisms develop, individual cells generate mitochondria to fulfill physiological requirements. However, it remains unknown how mitochondrial network expansion is scaled to cell growth. The mitochondrial unfolded protein response (UPR^mt) is a signaling pathway mediated by the transcription factor ATFS-1 which harbors a mitochondrial targeting sequence (MTS). Here, using the model organism Caenorhabditis elegans we demonstrate that ATFS-1 mediates an adaptable mitochondrial network expansion program that is active throughout normal development. Mitochondrial network expansion requires the relatively inefficient MTS in ATFS-1, which allows the transcription factor to be responsive to parameters that impact protein import capacity of the mitochondrial network. Increasing the st

SUBMITTER: Shpilka T 

PROVIDER: S-EPMC7817664 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature