Excessive salt consumption causes systemic calcium mishandling and worsens microarchitecture and strength of long bones in rats.

ABSTRACT: Excessive salt intake has been associated with the development of non-communicable diseases, including hypertension with several cardiovascular consequences. Although the detrimental effects of high salt on the skeleton have been reported, longitudinal assessment of calcium balance together with changes in bone microarchitecture and strength under salt loading has not been fully demonstrated. To address these unanswered issues, male Sprague-Dawley rats were fed normal salt diet (NSD; 0.8% NaCl) or high salt diet (HSD; 8% NaCl) for 5 months. Elevation of blood pressure, cardiac hypertrophy and glomerular deterioration were observed in HSD, thus validating the model. The balance studies were performed to monitor calcium input and output upon HSD challenge. The HSD-induced increase in calcium

SUBMITTER: Tiyasatkulkovit W 

PROVIDER: S-EPMC7817681 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature