Gel formulations of Merremia mammosa (Lour.) accelerated wound healing of the wound in diabetic rats.

ABSTRACT:

Background and aim

The treatment of diabetic ulcers is difficult because of defective blood vessels and frequent co-occurrence of bacterial infections. In a previous study, we found a water fraction of Merremia mammosa (Lour.) (Mm(Lour.)) had beneficial effects on wound healing in diabetic rats. This study aimed to evaluate the influence of different gelling agents added to Mm(Lour.) water fraction gel on wound healing treatment in diabetic rats.

Experimental procedure

Diabetic Wistar rats were divided into the following five groups: 1. positive control (Neomycin Sulfate 0.5% and Placenta Extract 10%), 2. negative control (distilled water), and 10% water fraction of Mm(Lour.) extract in 3. HPMC, 4. Carbopol, and 5. CMC Na gelling agents. The wound was ma

SUBMITTER: Marchianti ACN 

PROVIDER: S-EPMC7817712 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature