Use of tyrosine kinase inhibitors for paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia: a systematic review and meta-analysis.

ABSTRACT:

Objectives

To investigate the effectiveness and safety of tyrosine kinase inhibitors (TKIs) in the management of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ALL).

Design

A systematic review and meta-analysis.

Data sources

Electronic searches were conducted on CENTRAL, MEDLINE, EMBASE, SIOP, ASPHO, ASCO, ASH and four Chinese databases from inception to 8 March 2020. Language of publications was restricted in English and Chinese.

Eligibility criteria

Prospective and retrospective comparative studies were included.

Data extraction and synthesis

Two authors independently assessed and extracted data. Quality of studies was assessed by the Cochrane Collaboration's tool and Newcastle-Ottawa Scale. Subgroup analysis was performe

SUBMITTER: Chen M 

PROVIDER: S-EPMC7817804 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature