Evaluation of articular cartilage with quantitative MRI in an equine model of post-traumatic osteoarthritis.

ABSTRACT: Chondral lesions lead to degenerative changes in the surrounding cartilage tissue, increasing the risk of developing post-traumatic osteoarthritis (PTOA). This study aimed to investigate the feasibility of quantitative magnetic resonance imaging (qMRI) for evaluation of articular cartilage in PTOA. Articular explants containing surgically induced and repaired chondral lesions were obtained from the stifle joints of seven Shetland ponies (14 samples). Three age-matched nonoperated ponies served as controls (six samples). The samples were imaged at 9.4 T. The measured qMRI parameters included T₁ , T₂ , continuous-wave T_1ρ (CWT_1ρ ), adiabatic T_1ρ (AdT_1ρ ), and T_2ρ (AdT_2ρ ) and relaxation along a fictitious

SUBMITTER: Kajabi AW 

PROVIDER: S-EPMC7818146 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature