Signs of Chronic Hypoxia Suggest a Novel Pathophysiological Event in α-Synucleinopathies.

ABSTRACT:

Background

Multiple system atrophy (MSA) and Parkinson's disease (PD) patients develop respiratory and cardiovascular disturbances including obstructive sleep apnea, orthostatic hypotension, and nocturnal stridor. We hypothesized that, associated with these respiratory and cardiovascular disturbances, hypoxic events may occur in MSA and PD brains that may play a role in disease progression. The objective of this study was to evaluate the presence of hypoxia in nonneurological controls and PD and MSA patients.

Methods

Molecular levels of hypoxia markers were measured in postmortem brain tissue from controls and PD and MSA cases.

Results

MSA brain showed signs of chronic hypoxia characterized by the significant accumulation of the hypoxic marker HIF2α as compared to PD

SUBMITTER: Heras-Garvin A 

PROVIDER: S-EPMC7818169 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature