Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women.

ABSTRACT:

Importance

Risk profiles for premature coronary heart disease (CHD) are unclear.

Objective

To examine baseline risk profiles for incident CHD in women by age at onset.

Design, setting, and participants

A prospective cohort of US female health professionals participating in the Women's Health Study was conducted; median follow-up was 21.4 years. Participants included 28 024 women aged 45 years or older without known cardiovascular disease. Baseline profiles were obtained from April 30, 1993, to January 24, 1996, and analyses were conducted from October 1, 2017, to October 1, 2020.

Exposures

More than 50 clinical, lipid, inflammatory, and metabolic risk factors and biomarkers.

Main outcomes and measures

Four age groups were examined (<55, 55 to <65, 65 to

SUBMITTER: Dugani SB 

PROVIDER: S-EPMC7818181 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature