A systematic review on mutation markers for bladder cancer diagnosis in urine.

ABSTRACT:

Objectives

To systematically summarise the available evidence on urinary bladder cancer (BC) mutation markers. Gene mutations are expected to provide novel biomarkers for urinary BC diagnosis. To date, evidence on urinary BC mutation markers has not proven sufficient to be adopted by clinical guidelines. In the present systematic review, diagnostic accuracy of urinary mutation analysis is separately assessed for primary BC diagnosis (BC detection) and for follow-up of BC patients (BC surveillance).

Methods

A literature search (PubMed, Embase.com and Wiley/Cochrane Library) and systematic review was performed up to 31 October 2019. As studies were too heterogeneous, no quantitative analysis could be performed.

Results

In total, 25 studies were summarised by qualitative

SUBMITTER: Hentschel AE 

PROVIDER: S-EPMC7818192 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature