Faecal calprotectin and gut microbiota do not predict enteropathy in very preterm infants.

ABSTRACT:

Aim

Very preterm birth is associated with a high risk of enteropathies. Diagnosis is challenging, especially in mild forms, leading to unnecessary periods of cessation of enteral feeding. This study aimed at establishing a prognosis score of enteropathy combining clinical parameters and faecal calprotectin concentration.

Methods

This prospective multicentric study included preterm neonates born at a gestational age of 33 weeks or less. Stools were collected weekly until hospital discharge, and daily in case of digestive events for calprotectin measurement (ELISA and immunochromatography) and microbiota analyses (16S rRNA gene sequencing).

Results

Among the 121 neonates included, 21 experienced at least one episode of enteropathy, mainly mild forms. By ELISA testing, m

SUBMITTER: Campeotto F 

PROVIDER: S-EPMC7818215 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature