Idarubicin-Gold Complex: From Crystal Growth to Gold Nanoparticles.

ABSTRACT: Idarubicin (IDA) is the analog of daunorubicin (DNR). The absence of the methoxy group at position 4 of IDA remarkably improved lipophilicity, which is responsible for extra cellular uptake, higher DNA-binding ability, and considerable cytotoxicity in correlation with doxorubicin (DOX) and DNR. In this paper, we conceived two principal objectives: we realized the crystal structure of IDA by X-ray diffraction measurements on single crystals at room temperature (monoclinic, space group P2₁, a = 5.1302(2) Å, b = 9.9122(5) Å, c = 24.8868(11) Å; β = 91.425(4)°; V = 1265.14(10) ų) with refinements of the structure converged to the final R = 3.87%. The second objective has been to develop gold nanoparticles encapsulated with idarubi

SUBMITTER: Barbey C 

PROVIDER: S-EPMC7818310 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature