Association of Baseline Characteristics With Insulin Sensitivity and β-Cell Function in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study Cohort.

ABSTRACT:

Objective

We investigated sex and racial differences in insulin sensitivity, β-cell function, and glycated hemoglobin (HbA_1c) and the associations with selected phenotypic characteristics.

Research design and methods

This is a cross-sectional analysis of baseline data from 3,108 GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) participants. All had type 2 diabetes diagnosed <10 years earlier and were on metformin monotherapy. Insulin sensitivity and β-cell function were evaluated using the HOMA of insulin sensitivity and estimates from oral glucose tolerance tests, including the Matsuda Index, insulinogenic index, C-peptide index, and oral disposition index (DI).

Results

The cohort was 56.6 ± 10 years of age (mean ± SD),

SUBMITTER: Rasouli N 

PROVIDER: S-EPMC7818323 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature