Effect of environmental tobacco smoke on COX-2 and SHP-2 expression in a periodontitis rat model.

ABSTRACT:

Objectives

To investigate the effects of environmental tobacco smoke (ETS) on the inflammatory process of periodontitis by evaluating bone loss and the expression of cyclooxygenase-2 (COX-2) and Src homology phosphotyrosine phosphatase 2 (SHP-2).

Materials and methods

Eighty 6-month-old male SD rats were randomized into four groups (10 rats/group/per time point): (a) normal group, (b) ETS group, (c) ligature-induced periodontitis group, and (d) ligature-induced periodontitis + ETS group. After treatment with ligature and/or ETS for 8 and 12 weeks, the levels of alveolar bone resorption and the expressions of COX-2 and SHP-2 in periodontal tissue were analyzed using histology and immunohistochemistry.

Results

The ligature-induced periodontitis group displayed increased

SUBMITTER: Li X 

PROVIDER: S-EPMC7818459 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature