Validation of the Model for End-stage Liver Disease sodium (MELD-Na) score in the Eurotransplant region.

ABSTRACT: The MELD score is used in the Eurotransplant (ET) region to allocate liver grafts. Hyponatremia in cirrhotic patients is an important predictor of death but is not incorporated in MELD. This study investigated the performance of the MELD-Na score for the ET region. All adult patients with chronic liver disease on the ET liver transplantation waiting list (WL) allocated through lab MELD scores were included. The MELD-corrected effect of serum sodium (Na) concentration at listing on the 90-day WL mortality was calculated using Cox regression. The MELD-Na performance was assessed with c-indices, calibration per decile and Brier scores. The reclassification from MELD to MELD-Na score was calculated to estimate the impact of MELD-Na-based allocation in the ET region. For the 5223 included patie

SUBMITTER: Goudsmit BFJ 

PROVIDER: S-EPMC7818465 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature