Recommendations for Multicentre Clinical Trials Involving Dosimetry for Molecular Radiotherapy.

ABSTRACT: Multicentre clinical trials involving a dosimetry component are becoming more prevalent in molecular radiotherapy and are essential to generate the evidence to support individualised approaches to treatment planning and to ensure that sufficient patients are recruited to achieve the statistical significance required. Quality assurance programmes should be considered to support the standardisation required to achieve meaningful results. Trials should be designed to ensure that dosimetry results from image acquisition systems across centres are comparable by incorporating steps to standardise the methodologies used for the quantification of images and dosimetry. Furthermore, it is essential to assess the expertise and resources available at each participating site prior to trial commencement

SUBMITTER: Taprogge J 

PROVIDER: S-EPMC7818526 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature