Infections or Sepsis Preceding Clinically Diagnosed α-Synucleinopathies: A Case-Control Study.

ABSTRACT:

Background

Several studies have proposed a role for infections to induce an inflammatory response triggering Parkinson's disease. This remains controversial and the influence of severe infections on other α-synucleinopathies (Dementia with Lewy Bodies, Parkinson's disease dementia, and Multiple System Atrophy) has not been adequately investigated.

Objectives

To assess the association between hospitalization-required infections or sepsis and risk of clinically diagnosed α-synucleinopathies.

Methods

Using the medical records-linkage system (Rochester Epidemiology Project), we identified all α-synucleinopathy cases of in Olmsted County (1991-2010). Cases were matched by symptom-onset age and sex to controls. We reviewed complete medical records to detect hospital-require

SUBMITTER: Hasan S 

PROVIDER: S-EPMC7818650 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature