Polymer Brush-Grafted Nanoparticles Preferentially Interact with Opsonins and Albumin.

ABSTRACT: Nanoparticles find increasing applications in life science and biomedicine. The fate of nanoparticles in a biological system is determined by their protein corona, as remodeling of their surface properties through protein adsorption triggers specific recognition such as cell uptake and immune system clearance and nonspecific processes such as aggregation and precipitation. The corona is a result of nanoparticle-protein and protein-protein interactions and is influenced by particle design. The state-of-the-art design of biomedical nanoparticles is the core-shell structure exemplified by superparamagnetic iron oxide nanoparticles (SPIONs) grafted with dense, well-hydrated polymer shells used for biomedical magnetic imaging and therapy. Densely grafted polymer chains form a polymer brush, yie

SUBMITTER: Leitner NS 

PROVIDER: S-EPMC7818653 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature