Old men with prostate cancer have higher risk of Gleason score upgrading and pathological upstaging after initial diagnosis: a systematic review and meta-analysis.

ABSTRACT:

Background

To evaluate the predictive performance of age for the risk of Gleason score change and pathologic upstaging.

Evidence acquisition

Ovid MEDLINE, Ovid Embase, and the Cochrane Library were searched from inception until May 2020. Quality of included studies was appraised utilizing the Newcastle-Ottawa Quality Assessment Scale for case-control studies. The publication bias was evaluated by funnel plots and Egger's tests.

Evidence synthesis

Our search yielded 27 studies with moderate-to-high quality including 84296 patients with mean age of 62.1 years. From biopsy to prostatectomy, upgrading and upstaging occurred in 32.3% and 9.8% of patients, respectively. Upgrading from diagnostic biopsy to confirmatory biopsy was found in 16.8%. Older age was associated with

SUBMITTER: Wang X 

PROVIDER: S-EPMC7818761 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature