Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers.

ABSTRACT: Cognitive impairment is a common clinical manifestation of multiple sclerosis, but its pathophysiology is not completely understood. White and grey matter injury together with synaptic dysfunction do play a role. The measurement of biomarkers in the cerebrospinal fluid and the study of their association with cognitive impairment may provide interesting in vivo evidence of the biological mechanisms underlying multiple sclerosis-related cognitive impairment. So far, only a few studies on this topic have been published, giving interesting results that deserve further investigation. Cerebrospinal fluid biomarkers of different pathophysiological mechanisms seem to reflect different neuropsychological patterns of cognitive deficits in multiple sclerosis. The aim of this review is to discuss the

SUBMITTER: Gaetani L 

PROVIDER: S-EPMC7818856 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature