Network pharmacology based research into the effect and mechanism of Yinchenhao Decoction against Cholangiocarcinoma.

ABSTRACT:

Background

Cholangiocarcinoma refers to an epithelial cell malignancy with poor prognosis. Yinchenhao decoction (YCHD) showed positive effects on cancers, and associations between YCHD and cholangiocarcinoma remain unclear. This study aimed to screen out the effective active components of Yinchenhao decoction (YCHD) using network pharmacology, estimate their potential targets, screen out the pathways, as well as delve into the potential mechanisms on treating cholangiocarcinoma.

Methods

By the traditional Chinese medicine system pharmacology database and analysis platform (TCMSP) as well as literature review, the major active components and their corresponding targets were estimated and screened out. Using the software Cytoscape 3.6.0, a visual network was established using

SUBMITTER: Chen Z 

PROVIDER: S-EPMC7818939 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature