Lung retention and particokinetics of silver and gold nanoparticles in rats following subacute inhalation co-exposure.

ABSTRACT:

Background

Inhalation exposure to nanomaterials in workplaces can include a mixture of multiple nanoparticles. Such ambient nanoparticles can be of high dissolution or low dissolution in vivo and we wished to determine whether co-exposure to particles with different dissolution rates affects their biokinetics.

Methods and results

Rats were exposed to biosoluble silver nanoparticles (AgNPs, 10.86 nm) and to biopersistent gold nanoparticles (AuNPs, 10.82 nm) for 28 days (6-h/day, 5-days/week for 4 weeks) either with separate NP inhalation exposures or with combined co-exposure. The separate NPs mass concentrations estimated by the differential mobility analyzer system (DMAS) were determined to be 17.68 ± 1.69 μg/m³ for AuNP and 10.12 ± 0.71 μg/m³ for AgNP

SUBMITTER: Kim JK 

PROVIDER: S-EPMC7819173 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature