rpoB mutations conferring rifampicin-resistance affect growth, stress response and motility in Vibrio vulnificus.

ABSTRACT: Rifampicin is a broad-spectrum antibiotic that binds to the bacterial RNA polymerase (RNAP), compromising DNA transcription. Rifampicin resistance is common in several microorganisms and it is typically caused by point mutations in the gene encoding the β subunit of RNA polymerase, rpoB. Different rpoB mutations are responsible for various levels of rifampicin resistance and for a range of secondary effects. rpoB mutations conferring rifampicin resistance have been shown to be responsible for severe effects on transcription, cell fitness, bacterial stress response and virulence. Such effects have never been investigated in the marine pathogen Vibrio vulnificus, even though rifampicin-resistant strains of V. vulnificus have been isolated previously. Moreov

SUBMITTER: Cutugno L 

PROVIDER: S-EPMC7819355 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature