Multimodal in vivo and postmortem assessments of tau in Lewy body disorders.
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ABSTRACT:
SUBMITTER: Coughlin DG
PROVIDER: S-EPMC7819484 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Multimodal in vivo and postmortem assessments of tau in Lewy body disorders.
Coughlin David G DG Phillips Jeffrey S JS Roll Emily E Peterson Claire C Lobrovich Rebecca R Rascovsky Katya K Ungrady Molly M Wolk David A DA Das Sandhitsu S Weintraub Daniel D Lee Edward B EB Trojanowski John Q JQ Shaw Leslie M LM Vaishnavi Sanjeev S Siderowf Andrew A Nasrallah Ilya M IM Irwin David J DJ McMillan Corey T CT
Neurobiology of aging 20200821
We compared regional retention of <sup>18</sup>F-flortaucipir between 20 patients with Lewy body disorders (LBD), 12 Alzheimer's disease patients with positive amyloid positron emission tomography (PET) scans (AD+Aβ) and 15 healthy controls with negative amyloid PET scans (HC-Aβ). In LBD subjects, we compared the relationship between <sup>18</sup>F-flortaucipir retention and cerebrospinal fluid (CSF) tau, cognitive performance, and neuropathological tau at autopsy. The LBD cohort was stratified ...[more]
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Project description:BackgroundAlzheimer's disease co-pathology is common in dementia with Lewy bodies and Parkinson's disease with dementia (Lewy body disease) and can reliably be detected with positron emission tomography (PET) or cerebrospinal fluid (CSF) biomarkers. Recently developed blood biomarkers are more accessible and less expensive alternatives.ObjectiveTo investigate if plasma phospho-tau217 and phospho-tau181 can detect Alzheimer's pathology in Lewy body disease with dementia.MethodsIn this cross-sectional study we investigated plasma phospho-tau217 and phospho-tau181 in 35 patients with Lewy body disease with dementia. Patients underwent tau-PET imaging (18 F-RO948).ResultsPlasma phospho-tau217 correlated with plasma phospho-tau181, CSF phospho-tau217 (rs = 0.68, P < 0.001), and negatively with CSF β-amyloid42/40 (rs = -0.52, P = 0.001). Plasma phospho-tau217 and phospho-tau181 correlated with tau-PET signal in the temporal cortex (rs > 0.56, P < 0.001) and predicted abnormal tau-PET status and β-amyloid status (area under the curve > 0.78 and > 0.81, respectively).ConclusionPlasma phospho-tau might be a useful marker for Alzheimer's co-pathology in Lewy body disease with dementia. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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