Rifampicin Can Be Given as Flat-Dosing Instead of Weight-Band Dosing.

ABSTRACT:

Background

The weight-band dosing in tuberculosis treatment regimen has been implemented in clinical practice for decades. Patients will receive different number of fixed dose combination tablets according to their weight-band. However, some analysis has shown that weight was not the best covariate to explain variability of rifampicin exposure. Furthermore, the rationale for using weight-band dosing instead of flat-dosing becomes questionable. Therefore, this study aimed to compare the average and the variability of rifampicin exposure after weight-band dosing and flat-dosing.

Methods

Rifampicin exposure were simulated using previously published population pharmacokinetics model at dose 10-40 mg/kg for weight-band dosing and dose 600-2400 mg for flat-dosing. The median area

SUBMITTER: Susanto BO 

PROVIDER: S-EPMC7819529 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature