Patterns of prenatal antidepressant exposure and risk of preeclampsia and postpartum haemorrhage.

ABSTRACT:

Background

Antidepressant use later in pregnancy has been associated with preeclampsia and postpartum haemorrhage (PPH) in some studies.

Objectives

To evaluate the association between patterns of prenatal antidepressant dose across gestationand risk of precclampsia and PPH.

Methods

We utilised OptumLabs® Data Warehouse (2012-2016) administrative health care claims, identifying 226 932 singleton liveborn deliveries for this retrospective cohort study. Antidepressant dispensing doses were converted to fluoxetine equivalents. Using k-means longitudinal, we identified women with similar patterns of antidepressant exposure, that is, trajectory groups, during the first 20 and 35 gestational weeks. We estimated risk ratios (RR) and 95% confidence intervals (CI) for the assoc

SUBMITTER: Palmsten K 

PROVIDER: S-EPMC7819597 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature