CD39⁺ Regulatory T Cells Attenuate Lipopolysaccharide-Induced Acute Lung Injury via Autophagy and the ERK/FOS Pathway.

ABSTRACT: Acute respiratory distress syndrome (ARDS) is characterized by an uncontrollable cytokine storm, which is associated with high mortality due to lack of effective treatment. Regulatory T cells (Tregs) play an indispensable role in maintaining immune homeostasis and CD39 is considered as a functional cell marker of Tregs. In this study, we aimed to evaluate the effect of CD39⁺ Tregs on acute lung injury (ALI) and investigate the frequency of CD39⁺ Tregs in ARDS patients. We found that after lipopolysaccharide (LPS) treatment, CD39^-/- mice exhibited more severe inflammation and wild type (WT) mice exhibited a decreased frequency of CD39⁺ Tregs in the peripheral blood. Furthermore, CD39⁺ Tregs had a protective effect on LPS-induced inflamm

SUBMITTER: Chen C 

PROVIDER: S-EPMC7819860 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature