Ochratoxin A affects oocyte maturation and subsequent embryo developmental dynamics in the juvenile sheep model.

ABSTRACT: The genotoxic and nephrotoxic mycotoxin Ochratoxin A (OTA) has also been reported to have adverse effects on oocyte maturation and embryo development. Previous studies on the effects of OTA on female fertility have used micromolar concentrations, but no information is available to date on effects in a more relevant nanomolar range. This study used a juvenile sheep model to evaluate the effects of oocyte exposure to low levels of OTA on maturation, fertilization, and embryo development. Further, it was investigated whether different mechanisms of action of OTA could be responsible for varying toxic effects at different levels of exposure. Cumulus-oocyte-complexes (COCs) were exposed to 10 μmol/L-0.1 nmol/L OTA during in vitro maturation and evaluated for cumulus viability, oocyte maturation

SUBMITTER: Dell'Aquila ME 

PROVIDER: S-EPMC7819917 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature