Role of c-Fos in orthodontic tooth movement: an in vivo study using transgenic mice.

ABSTRACT:

Objectives

The transcription factor c-Fos controls the differentiation of osteoclasts and is expressed in periodontal ligament cells after mechanical stimulation in vitro. However, it is unclear how c-Fos regulates orthodontic tooth movement (OTM) in vivo. The aim of this study was therefore to analyse OTM in transgenic mice with overexpression of c-Fos.

Materials and methods

We employed c-Fos transgenic mice (c-Fos tg) and wild-type littermates (WT) in a model of OTM induced by Nitinol tension springs that were bonded between the left first maxillary molars and the upper incisors. The unstimulated contralateral side served as an internal control. Mice were analysed by contact radiography, micro-computed tomography, decalcified histology and histochemistry.

Results

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SUBMITTER: Decker MG 

PROVIDER: S-EPMC7819946 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature