Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer.

ABSTRACT:

Background

Recently, microRNAs have been demonstrated to be potential non-invasive biomarkers for diagnosis, prognosis assessment or prediction of response to treatment in cancer. In this study, we evaluate the potential of miR-30b-5p as a biomarker for early diagnosis of breast cancer (BC) in tissue and plasma.

Methods

Expression of miR-30b-5p was determined in a series of 112 BC and 40 normal breast tissues. Circulating miR-30b-5p levels in plasma samples were determined in a discovery cohort of 38 BC patients and 40 healthy donors and in a validation cohort of 83 BC patients and 83 healthy volunteers. miR-30b-5p expression was measured by quantitative real-time PCR and receiver operating characteristics curve analysis was carried out.

Results

The miR-30b-5p express

SUBMITTER: Adam-Artigues A 

PROVIDER: S-EPMC7820029 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature