Pallidal Deep Brain Stimulation for Monogenic Dystonia: The Effect of Gene on Outcome.

ABSTRACT: Globus pallidus internus deep brain stimulation (GPi DBS) is the most effective intervention for medically refractory segmental and generalized dystonia in both children and adults. Predictive factors for the degree of improvement after GPi DBS include shorter disease duration and dystonia subtype with idiopathic isolated dystonia usually responding better than acquired combined dystonias. Other factors contributing to variability in outcome may include body distribution, pattern of dystonia and DBS related factors such as lead placement and stimulation parameters. The responsiveness to DBS appears to vary between different monogenic forms of dystonia, with some improving more than others. The first observation in this regard was reports of superior DBS outcomes in DYT-TOR1A (DYT1) dystoni

SUBMITTER: Tisch S 

PROVIDER: S-EPMC7820073 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature