Opposite correlation of 25-hydroxy-vitamin D- and 1,25-dihydroxy-vitamin D-metabolites with gestational age, bone- and lipid-biomarkers in pregnant women.

ABSTRACT: 25-Hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)₂D) need to be bound to carrier proteins to be transported to their target cells. The majority of either 25OHD or 1,25(OH)₂D is bound to vitamin D-binding protein (DBP), a smaller fraction is bound to albumin and only very small amounts of 25OHD or 1,25(OH)₂D are free. Albumin-bound 25OHD or 1,25(OH)₂D is relatively easily available after dissociation from albumin. Thus, the sum of free and albumin-bound forms is called bioavailable 25OHD and bioavailable 1,25(OH)₂D. Total 25OHD and 1,25(OH)₂D are defined as the sum of free, albumin-bound and DBP-bound 25OHD and 1,25(OH)₂D, respectively. This cross-sectional study in 427 pregnant women compared the c

SUBMITTER: Tsuprykov O 

PROVIDER: S-EPMC7820257 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature