Brain dynamics: the temporal variability of connectivity, and differences in schizophrenia and ADHD.

ABSTRACT: We describe advances in the understanding of brain dynamics that are important for understanding the operation of the cerebral cortex in health and disease. In data from 1017 participants from the Human Connectome Project, we show that early visual and connected areas have low temporal variability of their functional connectivity. We show that a low temporal variability of the connectivity of cortical areas is related to high mean functional connectivity between those areas, and provide an account of how these dynamics arise. We then investigate how these concepts help to understand brain dynamics in mental disorders. We find that in both first episode and long-term schizophrenia, reduced functional connectivity of early visual and related temporal cortex areas is associated with increased

SUBMITTER: Rolls ET 

PROVIDER: S-EPMC7820440 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature