Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review.

ABSTRACT: Inflammation is increasingly recognized as a cause or consequence of common problems of humanity including obesity, stress, depression, pollution and disease states such as autoimmunity, asthma, and infection. Maternal immune activation (MIA), triggered by both acute and systemic chronic inflammation, is hypothesized to be one of the mechanisms implicated in the pathogenesis of neurodevelopmental disorders (NDD). Although there is substantial preclinical evidence to support the MIA hypothesis, the human evidence is disparate. We performed a systematic review on human studies examining associations between maternal inflammatory states and offspring NDDs (autism spectrum disorder- ASD, attention deficit hyperactivity disorder-ADHD, Tourette syndrome-TS). 32 meta-analyses and 26 additional in

SUBMITTER: Han VX 

PROVIDER: S-EPMC7820474 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature