Network analysis of Down syndrome and SARS-CoV-2 identifies risk and protective factors for COVID-19.

ABSTRACT: SARS-CoV-2 infection has spread uncontrollably worldwide while it remains unknown how vulnerable populations, such as Down syndrome (DS) individuals are affected by the COVID-19 pandemic. Individuals with DS have more risk of infections with respiratory complications and present signs of auto-inflammation. They also present with multiple comorbidities that are associated with poorer COVID-19 prognosis in the general population. All this might place DS individuals at higher risk of SARS-CoV-2 infection or poorer clinical outcomes. In order to get insight into the interplay between DS genes and SARS-cov2 infection and pathogenesis we identified the genes associated with the molecular pathways involved in COVID-19 and the host proteins interacting with viral proteins from SARS-CoV-2. We then

SUBMITTER: De Toma I 

PROVIDER: S-EPMC7820501 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature