Single-cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-bet⁺ B cells.

ABSTRACT:

Background

Traditional laboratory model organisms represent a small fraction of the diversity of multicellular life, and findings in any given experimental model often do not translate to other species. Immunology research in non-traditional model organisms can be advantageous or even necessary, such as when studying host-pathogen interactions. However, such research presents multiple challenges, many stemming from an incomplete understanding of potentially species-specific immune cell types, frequencies, and phenotypes. Identifying and characterizing immune cells in such organisms is frequently limited by the availability of species-reactive immunophenotyping reagents for flow cytometry, and insufficient prior knowledge of cell type-defining markers.

Results

Here, we demons

SUBMITTER: Patel RS 

PROVIDER: S-EPMC7820527 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature