Comorbid disease burden among MS patients 1968-2012: A Swedish register-based cohort study.

ABSTRACT:

Background

People with multiple sclerosis (pwMS) have increased comorbid disease (CMD) risk. Most previous studies have not considered overall CMD burden.

Objective

To describe lifetime CMD burden among pwMS.

Methods

PwMS identified using Swedish registers between 1968 and 2012 (n = 25,476) were matched by sex, age, and county of residence with general-population comparators (n = 251,170). Prevalence, prevalence ratios (PRs), survival functions, and hazard ratios by MS status, age, and time period compared seven CMD: autoimmune, cardiovascular, depression, diabetes, respiratory, renal, and seizures.

Results

The magnitude of the PRs for each CMD and age group decreased across time, with higher PRs in earlier time periods. Before 1990, younger age g

SUBMITTER: Smith KA 

PROVIDER: S-EPMC7820574 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature